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Gibco
PeproGMP® Human BMP-4 Recombinant Protein, PeproTech®
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PeproGMP® Human BMP-4 Protein (GMP120-05ET-50UG) in Functional
Product Details
GMP120-05ET-50UG
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Product Specific Information
PeproTech E.coli-derived Human BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor, as well as an N-terminal Methionine. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 24.2 kDa.
Additional product information and specifications are provided on the Certificate of Analysis.
Note: All PeproGMP® products are manufactured using animal-derived component free materials.
Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.
Target Information
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.
References (0)
Bioinformatics
Protein Aliases: BMP; BMP-2B; BMP-4; Bone morphogenetic protein; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein
Gene Aliases: BMP2B; BMP2B1; BMP4; DVR4; MCOPS6; OFC11; ZYME
UniProt ID: (Human) P12644
Entrez Gene ID: (Human) 652
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