Invitrogen

PXR (SXR) Ligand Binding Domain Protein, GST Tag Recombinant Protein

Name: PXR (SXR) Ligand Binding Domain Protein, GST Tag Recombinant Protein
Brand: Invitrogen
SKU: PV4841

View all (4) PXR proteins

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PV4841

Applications

Tested Dilution

Publications

Ligand Binding Assay (LBA)

Assay-dependent

Product Specifications

Species

Human

Expression System

Baculovirus

Amino acid sequence

111-434

Tag

GST-tag

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

purified

Storage buffer

proprietary buffer

Contains

no preservative

Storage conditions

-80°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Dry ice

Product Specific Information

Pregnane X Receptor (Steroid and Xenobiotic Receptor), Ligand Binding Domain (PXR (SXR)-LBD) is a 64.7 kDa recombinant human protein (amino acids 111-434) expressed as a GST fusion protein in baculovirus-infected insect cells. PXR (SXR)-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator recruitment or displacement studies.

Protein Form: Recombinant, Ligand Binding Domain

Target Information

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR q; pregnane X nuclear receptor variant 2; Pregnane X receptor; Steroid and xenobiotic receptor; SXR