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Invitrogen
Human Taok2 (aa 358-464) Control Fragment Recombinant Protein
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Product Details
RP-89791
Species
Expression System
Amino acid sequence
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Conjugate
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82401. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; Serine/threonine-protein kinase TAO2; tao; Thousand and one amino acid protein kinase 2
Gene Aliases: KIAA0881; MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431
UniProt ID: (Human) Q9UL54
Entrez Gene ID: (Human) 9344
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