Invitrogen

Human PUMA Synthetic Peptide

Name: Human PUMA Synthetic Peptide
Brand: Invitrogen
SKU: PEP-0128

View all (2) PUMA alpha proteins

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PEP-0128

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species Reactivity

Human

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

purified

Storage buffer

PBS, pH 7.2, with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This peptide corresponds to 15 amino amino terminus of human PUMA.

PEP-0128 can be used as a blocking peptide with polyclonal antibody PA5-20008.

Target Information

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; FLJ42994; JFY-1; p53 up-regulated modulator of apoptosis