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Invitrogen
Human PSTPIP1 (aa 306-415) Control Fragment Recombinant Protein
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Product Details
RP-90639
Species
Expression System
Amino acid sequence
Tag
Class
Type
Purity
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibodies, PA5-144691, PA5-52712. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; H-PIP; PEST phosphatase-interacting protein 1; Proline-serine-threonine phosphatase-interacting protein 1; truncated proline-serine-threonine phosphatase interacting protein 1
Gene Aliases: CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP; PSTPIP1
UniProt ID: (Human) O43586
Entrez Gene ID: (Human) 9051
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