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Invitrogen
Human PRTFDC1 Synthetic Peptide
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Product Details
PEP-0713
Species Reactivity
Class
Type
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Product Specific Information
This peptide corresponds to 14 amino acids near the center of human PRTFDC1
PEP-0713 can be used as a blocking peptide with polyclonal antibody PA5-20593.
Target Information
Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Phosphoribosyltransferase domain-containing protein 1
Gene Aliases: HHGP; PRTFDC1
UniProt ID: (Human) Q9NRG1
Entrez Gene ID: (Human) 56952
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