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Invitrogen
Human PNAS4 (aa 7-96) Control Fragment Recombinant Protein
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Product Details
RP-99772
Species
Expression System
Amino acid sequence
Tag
Class
Type
Purity
Conjugate
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Purification
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65589. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DeSI-2; desumoylating isopeptidase 1; Desumoylating isopeptidase 2; Deubiquitinase DESI2; family with sequence similarity 152, member A; Palmitoyl protein thioesterase DESI2; PPPDE peptidase domain-containing protein 1; Protein FAM152A; S-depalmitoylase DESI2
Gene Aliases: C1orf121; CGI-146; DESI; DeSI-2; DESI1; DESI2; FAM152A; PNAS-4; PPPDE1
UniProt ID: (Human) Q9BSY9
Entrez Gene ID: (Human) 51029
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