Invitrogen

Human PIK3CB/PIK3R2 (p110 beta/p85 beta), His Tag Recombinant Protein

Name: Human PIK3CB\/PIK3R2 (p110 beta\/p85 beta), His Tag Recombinant Protein
Brand: Invitrogen
SKU: A31084
Availability: InStock

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

A31084

Applications

Tested Dilution

Publications

Kinase Assay (KA)

Assay-dependent

Product Specifications

Species

Human

Expression System

Insect cells

Amino acid sequence

Full length

Tag

His-tag

Molecular weight

123.7-83.5 kDa

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

purified

Storage buffer

50mM sodium phosphate, pH 7, with 150mM Imidazole, 25% glycerol, 0.25mM DTT, 0.1mM PMSF, 300mM NaCl

Contains

no preservative

Storage conditions

-80°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Dry ice

Product Specific Information

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.

This PIK3CB/PIK3R2 (p110 beta/p85 beta) recombinant human protein (full length) was expressed in insect cells.

PIK3CB/PIK3R2 (p110 beta/p85 beta) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

Protein Form: Full Length, Recombinant, Active

The gene accession number for PIK3CB is NP_006210.1 and for PIK3R2 is NP_852664.1.

Target Information

PIK3CB/PIK3R2 lipid kinase (p110 beta/p85 beta) or Phosphatidylinositol 3-kinase (PI3K) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids which functions in signaling pathways that regulate cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kDa catalytic subunit and a 85-kDa adaptor subunit. PIK3CB plays a critical role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. PIK3CB sustains alpha-2B-beta-3 integrin activation and stabilized platelet aggregation by regulating both integrin-dependent calcium flux and Gi activation of RAP1B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3-kinase p110 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3K-beta; PIK3CB; PIK3R2; PtdIns-3-kinase p110; ptdIns-3-kinase regulatory subunit p85-beta; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB

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Gene Aliases: MPPH; MPPH1; P110BETA; p85; p85-BETA; P85B; PI3K; PI3KBETA; PIK3C1; PIK3CB; PIK3R2