Invitrogen

Human PIK3CB/PIK3R1 (p110 beta/p85 alpha), His Tag Recombinant Protein

Name: Human PIK3CB\/PIK3R1 (p110 beta\/p85 alpha), His Tag Recombinant Protein
Brand: Invitrogen
SKU: PV6454
Availability: InStock

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PV6454

Applications

Tested Dilution

Publications

Kinase Assay (KA)

Assay-dependent

Product Specifications

Species

Human

Expression System

Baculovirus

Amino acid sequence

Full length

Tag

His-tag

Molecular weight

123.7-84.7 kDa

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

purified

Storage buffer

50mM sodium phosphate, pH 7, with 25% glycerol, 0.1mM PMSF, 300mM NaCl, 0.25mM DTT, 150mM Imidazole

Contains

no preservative

Storage conditions

-80°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Dry ice

Product Specific Information

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.

PIK3CB/PIK3R1 (p110β/p85α) Recombinant Human Protein is:
• Available in 3 convenient sizes
• Validated in our Adapta™ and Kinase Binding assays
• A full-length protein that can help advance your research when used in validated assays

Related assay platforms:
LanthaScreen™ Kinase Binding Assay
Adapta™ Kinase Activity Assay

Protein Form: Full Length, Recombinant, Active

The gene accession number for PIK3CB (p110β) is NP_006210 and for PIK3R1 (p85α) is NP_852664.1.

Target Information

PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively. As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, catalytic, beta polypeptide; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p110 subunit beta; PI3-kinase regulatory subunit alpha; PI3-kinase subunit beta; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3K-beta; PIK3CB; PIK3R1; PtdIns-3-kinase p110; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB

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Gene Aliases: AGM7; GRB1; IMD36; P110BETA; p85; p85-ALPHA; PI3K; PI3KBETA; PIK3C1; PIK3CB; PIK3R1