Invitrogen

Human PHOX2A Synthetic Peptide

Name: Human PHOX2A Synthetic Peptide
Brand: Invitrogen
SKU: PEP-1424

View all (3) PHOX2A proteins

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PEP-1424

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species Reactivity

Human

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

purified

Storage buffer

PBS, pH 7.2, with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This peptide corresponds to 16 amino acid peptide near the carboxy terminus of human PHOX2A.

PEP-1424 can be used as a blocking peptide with polyclonal antibody PA5-34381.

Target Information

PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A