Invitrogen

Human PCSK9 (NARC1) His-tag Recombinant Protein

Name: Human PCSK9 (NARC1) His-tag Recombinant Protein
Brand: Invitrogen
SKU: RP-88142

View all (2) PCSK9 proteins

Datasheet

Tech Support

Datasheet

Tech Support

Testing Data (1)

Human PCSK9 (NARC1) His-tag Protein in SDS-PAGE (SDS-PAGE)

FIGURE: 1 / 1

Human PCSK9 (NARC1) His-tag Protein (RP-88142) in SDS-PAGE

SDS-PAGE analysis of Human PCSK9 (NARC1) His-tag (Product # RP-88142). The specification for purity shows: ≥ 95 % (SDS-PAGE), ≥ 95 % (SEC-HPLC).

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Product Details

RP-88142

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

Product Specifications

Species

Human

Expression System

HEK293 cells

Amino acid sequence

Human PCSK9, amino acids Met1-Gln692 (Accession # NP_777596.2) with a C-terminal His-tag

Tag

His-tag

Molecular weight

72.5 kDa

Class

Recombinant

Type

Protein

Purity

>95% as determined by SDS-PAGE.

Endotoxin concentration

<1.0 EU/µg

Activity

Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag on ProA Biosensor, can bind Recombinant Human PCSK9 Protein, His Tag with an affinity constant of 16nM as determined in BLI assay. Immobilized Anti-PCSK9(Amg)-IgG2 Antibody at 2 µg/mL (100 µL/well) can bind Recombinant Human PCSK9 / NARC1 Protein (His Tag), the EC50 is 14-52 ng/mL.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Storage buffer

PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

It is recommended that the protein be aliquoted for optimal storage.

It is recommended that sterile water (500µL) be added to the vial to prepare a stock solution of 1 mg/mL.

Concentration is measured by UV.

Target Information

PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9