Invitrogen

Human LAIR1 Fc Chimera Recombinant Protein

Name: Human LAIR1 Fc Chimera Recombinant Protein
Brand: Invitrogen
SKU: RP-88100

View all (2) LAIR1 (CD305) proteins

Datasheet

Tech Support

Datasheet

Tech Support

Testing Data (1)

Human LAIR1 Fc Chimera Protein in SDS-PAGE (SDS-PAGE)

FIGURE: 1 / 1

Human LAIR1 Fc Chimera Protein (RP-88100) in SDS-PAGE

SDS-PAGE analysis of Human LAIR1 Fc Chimera (Product # RP-88100) shows purity to be: > 95 % (SDS-PAGE).

Product Image Gallery

Product Details

RP-88100

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Product Specifications

Species

Human

Expression System

HEK293 cells

Amino acid sequence

Human LAIR1, amino acids Met1-Tyr165 (Accession # Q6GTX8.1) with a C-terminal human IgG1 Fc region

Tag

Fc-tag

Molecular weight

42.8 kDa

Class

Recombinant

Type

Protein

Purity

>95% as determined by SDS-PAGE.

Endotoxin concentration

<1.0 EU/µg

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Storage buffer

PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

It is recommended that the protein be aliquoted for optimal storage.

It is recommended that sterile water (1000 µL) be added to the vial to prepare a stock solution of 1 mg/mL.

Concentration is measured by UV.

Target Information

CD305, also known as LAIR1, is a type I transmembrane glycoprotein with an extracellular Ig-like domain and two intracellular ITIMs. It is expressed on a wide range of immune cells, including T, NK, and B cells, monocytes, dendritic cells, eosinophils, basophils, and mast cells. In humans, CD305 is also present on CD34+ hematopoietic progenitor cells and thymocytes. Several isoforms exist due to alternative splicing, with expression varying between cell types. CD305 functions as an inhibitory receptor, playing a key role in regulating immune responses. It blocks cytokine-mediated signaling, cell proliferation, and apoptosis. In NK, B, and T cells, CD305 modulates cytolytic functions and cytokine production, down-regulating IL2 and IFNG in CD4+ T cells while inducing transforming growth factor beta. In B cells, it reduces IgG and IgE production and decreases IL8, IL10, and TNF secretion. Activation of CD305 through tyrosine phosphorylation recruits phosphatases PTPN6 and PTPN11, although it may also function independently of SH2-containing phosphatases. It inhibits differentiation of peripheral blood precursors into dendritic cells and has been shown to induce apoptosis in myeloid leukemia cell lines. Collagens are identified as ligands for CD305, underscoring its role in immune regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: CD305; immunoglobulin heavy chain variable region; LAIR-1; leukocyte-associated Ig-like receptor 1; Leukocyte-associated immunoglobulin-like receptor 1