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Gibco
Human IL-29 (IFN lambda-1) Recombinant Protein, PeproTech®
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Product Details
300-02L-20UG
Species
Published species
Expression System
Amino acid sequence
Molecular weight
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Conjugate
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Product Specific Information
Recombinant Human IFN-lambda1 is a 19.8 kDa protein containing 178 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low levels of costimulatory molecules. Moreover, these cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytokine Zcyto21; FNL1; IFN lambda1; IFN-lambda-1; IL-29; ILN; Interferon lambda-1; Interferon lambda1; interferon, lambda 1; interferon-lambda-1; Interleukin; interleukin 29 (interferon, lambda 1); Interleukin-29
Gene Aliases: IFNL1; IL-29; IL29; ZCYTO21
UniProt ID: (Human) Q8IU54
Entrez Gene ID: (Human) 282618
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