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Invitrogen
Human DNMBP (aa 389-468) Control Fragment Recombinant Protein
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Product Details
RP-106830
Species
Expression System
Amino acid sequence
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Conjugate
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (63%), Rat (63%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66148. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Dynamin-binding protein; Scaffold protein Tuba
Gene Aliases: ARHGEF36; DNMBP; KIAA1010; TUBA
UniProt ID: (Human) Q6XZF7
Entrez Gene ID: (Human) 23268
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