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Invitrogen
Human DNER (aa 203-329) Control Fragment Recombinant Protein
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Product Details
RP-90575
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (91%), Rat (91%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Delta and Notch-like epidermal growth factor-related receptor; delta-notch-like EGF repeat-containing transmembrane; delta/notch-like EGF repeat containing; H_NH0150O02.1; WUGSC:H_NH0150O02.1
Gene Aliases: BET; DNER; UNQ26; UNQ262/PRO299
UniProt ID: (Human) Q8NFT8
Entrez Gene ID: (Human) 92737
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