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Invitrogen
Human DERL2 (aa 217-239) Control Fragment Recombinant Protein
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Product Details
RP-101113
Species
Expression System
Amino acid sequence
Tag
Class
Type
Purity
Conjugate
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Concentration
Purification
Storage buffer
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61845. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: carcinoma related; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; Derlin-2; DERtrin-2; F-LAN-1; F-LANa
Gene Aliases: CGI-101; DER2; DERL2; DERtrin-2; F-LAN-1; F-LANa; FLANA; SBBI53
UniProt ID: (Human) Q9GZP9
Entrez Gene ID: (Human) 51009
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