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Invitrogen
Human DACT1 (aa 179-270) Control Fragment Recombinant Protein
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Product Details
RP-109418
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Amino acid sequence
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (89%), Rat (89%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Dapper homolog 1, an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism. Dapper homolog 1 acts as an interacting protein for Dvl, and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of Dapper homolog 1. The gene for human Dapper homolog 1 is localized on chromosomal region 14q23.1. The protein impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. The protein is also required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in human liver and various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Dapper antagonist of catenin 1; Dapper homolog 1; dapper, antagonist of beta-catenin, homolog 1; dishevelled-binding antagonist of beta-catenin 1; hDPR1; Hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3
Gene Aliases: DACT1; DAPPER; DAPPER1; DPR1; FRODO; HDPR1; HNG3; THYEX3
UniProt ID: (Human) Q9NYF0
Entrez Gene ID: (Human) 51339
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