Invitrogen

Human CRIM2 Synthetic Peptide

Name: Human CRIM2 Synthetic Peptide
Brand: Invitrogen
SKU: PEP-1453

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PEP-1453

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species Reactivity

Human

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

purified

Storage buffer

PBS, pH 7.2, with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This peptide corresponds to 15 amino acid peptide near the carboxy terminus of human CRIM2.

PEP-1453 can be used as a blocking peptide with polyclonal antibody PA5-34411.

Target Information

CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CRIM-2; cysteine rich BMP regulator 2 (chordin-like); Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; KCP-1; kielin; Kielin/chordin-like protein; Kielin/chordin-like protein 1