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Invitrogen
Human COG2 (aa 600-689) Control Fragment Recombinant Protein
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Product Details
RP-94222
Species
Expression System
Amino acid sequence
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Conjugate
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (75%), Rat (75%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67442. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG2 (conserved oligomeric Golgi complex subunit 2), also known as LDLC, is a 730 amino acid component of the COG complex. Localized to the cytoplasmic side of the Golgi apparatus, COG2 is required for proper Golgi morphology and function, specifically playing a role in Golgi ribbon formation and vesicular transport. Abnormal COG2 function may cause cell death, suggesting that COG2 is an important factor in cell viability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: brefeldin A-sensitive, peripheral Golgi protein; COG 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; conserved oligomeric Golgi complex protein 2; Conserved oligomeric Golgi complex subunit 2; low density lipoprotein receptor defect C complementing; Low density lipoprotein receptor defect C-complementing protein; Transcript ch4822
Gene Aliases: COG2; LDLC
UniProt ID: (Human) Q14746
Entrez Gene ID: (Human) 22796
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