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Invitrogen
Human CNNM3 (aa 582-685) Control Fragment Recombinant Protein
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Product Details
RP-91095
Species
Expression System
Amino acid sequence
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Type
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Conjugate
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (81%), Rat (81%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53478. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
CNNM3, also known as cyclin M3, is part of the CNNM family of proteins that play a critical role in magnesium ion transport across cellular membranes. This gene is notably expressed in the proximal tubule of the kidney, and its protein product localizes to the lateral membrane, suggesting its involvement in magnesium homeostasis. The structural analysis of the CNNM3 protein reveals it contains a cyclic nucleotide-binding homology domain with a characteristic beta-roll structure capped by an α-helical bundle, which is typical of cyclic nucleotide-binding domains. CNNM proteins were originally discovered in bacteria and are conserved across various organisms, indicating their fundamental biological importance. CNNM3 has been studied for its ability to decrease whole cellular magnesium content and free intracellular magnesium activity when expressed in model systems such as Xenopus laevis oocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: ancient conserved domain protein 3; Ancient conserved domain-containing protein 3; cyclin M3; Cyclin-M3; Metal transporter CNNM3
Gene Aliases: ACDP3; CNNM3
UniProt ID: (Human) Q8NE01
Entrez Gene ID: (Human) 26505
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