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Invitrogen
Human CNGA4 (aa 514-567) Control Fragment Recombinant Protein
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Product Details
RP-109765
Species
Expression System
Amino acid sequence
Tag
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Type
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Conjugate
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Purification
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (83%), Rat (83%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-145067. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: cng channel; CNG channel alpha-4; cyclic nucleotide gated channel beta 2; Cyclic nucleotide-gated channel alpha-4; OCNC2; Olfactory cyclic nucleotide-gated channel subunit 2
Gene Aliases: CNCA2; CNG-4; CNG4; CNG5; CNGA4; CNGB2; OCNC2; OCNCb; OCNCBETA
UniProt ID: (Human) Q8IV77
Entrez Gene ID: (Human) 1262
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