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Invitrogen
Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein
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Product Details
A33511
Species
Expression System
Amino acid sequence
Tag
Molecular weight
Class
Type
Conjugate
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Purification
Storage buffer
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Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CDK11/cyclin C recombinant human protein (CDK11: 1-502, cyclin C: 1-283) was expressed in insect cells.
CDK11/cyclin C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
The gene accession number for CDK11 and cyclin C are NP_055891.1 and NP_005181.2.
Target Information
CDK11 is a member of the cyclin-dependent kinase 11 family which is known to be essential for eukaryotic cell cycle control and it is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. CDK11 is a negative regulator of normal cell cycle progression and Its expression is regulated during murine embryogenesis, and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle. CDK11 gene may harbor 1 or more tumor suppressor genes that affected by chromosome 1p36 modifications in neuroblastoma. CDK11 could be cleaved by caspases and was demonstrated to play roles in cell apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CDC-related protein kinase p58; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2 (PITSLRE proteins); Cell division cycle 2-like protein kinase 1; Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Cell division protein kinase 11B; CLK-1; Cyclin-dependent kinase 11A; Cyclin-dependent kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; p58 CLK-1; PITSLRE B; PITSLRE protein kinase beta; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLRE serine/threonine-protein kinase CDC2L2
Gene Aliases: CDC2L1; CDC2L2; CDC2L3; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CDK11A; CDK11B; CLK-1; p58; p58CDC2L1; p58CLK-1; p58GTA; PITSLRE; PITSLREA; PITSLREB; PK58
UniProt ID: (Human) Q9UQ88, (Human) P21127
Entrez Gene ID: (Human) 728642, (Human) 984
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