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Invitrogen
Human CD53 (aa 111-180) Control Fragment Recombinant Protein
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Product Details
RP-91155
Species
Expression System
Amino acid sequence
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Conjugate
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (70%), Rat (70%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83861. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumor cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: antigen MOX44 identified by monoclonal antibody MRC-OX44; CD53; CD53 antigen; CD53 glycoprotein; CD53 tetraspan antigen; cell surface antigen; Cell surface glycoprotein CD53; Leukocyte surface antigen CD53; Tetraspanin-25; transmembrane glycoprotein; Tspan-25
Gene Aliases: CD53; MOX44; TSPAN25
UniProt ID: (Human) P19397
Entrez Gene ID: (Human) 963
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