Invitrogen

Human CCDC91 (aa 1-89) Control Fragment Recombinant Protein

Name: Human CCDC91 (aa 1-89) Control Fragment Recombinant Protein
Brand: Invitrogen
SKU: RP-97723

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

RP-97723

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species

Human

Expression System

E. coli

Amino acid sequence

MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQ

Tag

His-ABP-tag

Class

Recombinant

Type

Protein

Purity

>80% by SDS-PAGE and Coomassie blue staining

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

≥5.0 mg/mL

Purification

purified

Storage buffer

1M urea/PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Product Specific Information

Highest antigen sequence indentity to the following orthologs: Mouse (70%), Rat (70%).

This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58280. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Target Information

CCDC91 (Coiled-Coil Domain-Containing 91) is a gene located on chromosome 12q24.31 that encodes a protein involved in vesicle-mediated transport and Golgi function. The CCDC91 protein contains coiled-coil domains, which facilitate protein-protein interactions necessary for its role in the secretory pathway. Specifically, CCDC91 is a component of the Golgi-associated retrograde protein (GARP) complex, which is essential for the recycling of transport vesicles from endosomes to the trans-Golgi network (TGN). Research has revealed that CCDC91 is crucial for maintaining Golgi structure and function and is involved in the sorting and trafficking of proteins and lipids within the cell. The protein's interactions with other components of the vesicular transport machinery enable the efficient movement of cargo between organelles, which is critical for various cellular processes, including secretion, endocytosis, and lysosomal degradation. Mutations or dysregulation of CCDC91 can disrupt these processes, potentially leading to diseases associated with vesicle trafficking defects, such as certain neurodegenerative disorders and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Coiled-coil domain-containing protein 91; GGA binding partner; GGA-binding partner; p56 accessory protein