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Invitrogen
Human BCDIN3D (aa 196-292) Control Fragment Recombinant Protein
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Product Details
RP-97875
Species
Expression System
Amino acid sequence
Tag
Class
Type
Purity
Conjugate
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Purification
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (73%), Rat (73%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58979. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
O-methyltransferase that specifically monomethylates 5'- monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre- miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: BCDIN3 domain containing RNA methyltransfease; BCDIN3 domain-containing protein; probable methyltransferase BCDIN3D; RNA 5'-monophosphate methyltransferase
Gene Aliases: BCDIN3D
UniProt ID: (Human) Q7Z5W3
Entrez Gene ID: (Human) 144233
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