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Invitrogen
Human ARHGEF18 (aa 118-215) Control Fragment Recombinant Protein
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Product Details
RP-98918
Species
Expression System
Amino acid sequence
Tag
Class
Type
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Conjugate
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Purification
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (46%), Rat (46%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60083. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEF; Rho guanine nucleotide exchange factor 18; Rho-specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; SA-RhoGEF; Septin-associated RhoGEF
Gene Aliases: ARHGEF18; KIAA0521; P114-RhoGEF
UniProt ID: (Human) Q6ZSZ5
Entrez Gene ID: (Human) 23370
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