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Invitrogen
Human ARFGAP1 (aa 317-402) Control Fragment Recombinant Protein
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Product Details
RP-99305
Species
Expression System
Amino acid sequence
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Class
Type
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Conjugate
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Purification
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (69%), Rat (69%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84044. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
ArfGAP1 is a 406 amino acid containing regulatory protein with an Arf-GAP domain known to be involved in the activation of the GTPase activity of ADP ribosylation factor (ARF). ArfGAP1, a GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1), promotes the hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles thus playing an important role in membrane trafficking and/or vesicle transport. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been reported. Ubiquitous expression of ArfGAP1 is seen in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: ADP-ribosylation factor 1 GTPase-activating protein; ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase-activating protein 1; ARF GAP 1; ARF1 GAP; ARF1-directed GTPase-activating protein; GAP protein; RP11-261N11.1
Gene Aliases: ARF1GAP; ARFGAP1; HRIHFB2281
UniProt ID: (Human) Q8N6T3
Entrez Gene ID: (Human) 55738
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