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Invitrogen
Human APBA2 (aa 2-82) Control Fragment Recombinant Protein
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Product Details
RP-109203
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Expression System
Amino acid sequence
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Conjugate
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (83%), Rat (83%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); Amyloid-beta A4 precursor protein-binding family A member 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-like protein
Gene Aliases: APBA2; D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; X11-BETA; X11L
UniProt ID: (Human) Q99767
Entrez Gene ID: (Human) 321
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