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Invitrogen
Human APBA2 Synthetic Peptide
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Product Details
PEP-1167
Species Reactivity
Class
Type
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human APBA2.
PEP-1167 can be used as a blocking peptide with polyclonal antibody PA5-21053.
Target Information
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); Amyloid-beta A4 precursor protein-binding family A member 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-like protein
Gene Aliases: APBA2; D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; X11-BETA; X11L
UniProt ID: (Human) Q99767
Entrez Gene ID: (Human) 321
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