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Invitrogen
Human AIPL1 (aa 275-384) Control Fragment Recombinant Protein
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Product Details
RP-105767
Species
Expression System
Amino acid sequence
Tag
Class
Type
Purity
Conjugate
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Concentration
Purification
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Storage conditions
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (39%), Rat (39%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82924. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: aryl hydrocarbon receptor interacting protein-like 1; Aryl-hydrocarbon-interacting protein-like 1
Gene Aliases: AIPL1; AIPL2; LCA4
UniProt ID: (Human) Q9NZN9
Entrez Gene ID: (Human) 23746
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