Assay Details

Gene Symbol: IL12B
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_002187.2	NP_002178.2	4 - 5	524		129
GenBank mRNA	AF180563.1	-	3 - 4	488		129
	BC067498.1	-	3 - 4	486	6971868	129
	BC067499.1	-	3 - 4	486	6971869	129
	BC067500.1	-	3 - 4	486	6971872	129
	BC067501.1	-	3 - 4	486	6971873	129
	BC067502.1	-	3 - 4	486	6971874	129
	BC074723.2	-	4 - 5	513	30915173	129
	M65272.1	-	4 - 5	524		129
	M65290.1	-	3 - 4	495		129

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC0500012646.hg.1
This assay targets the same location as HTA transcript cluster(s) TC05001997.hg.1

Set Membership:

Ambion siRNA available

Amplicon length greater than or equal to 101

Immune Tolerance Network

Mammalian Gene Collection

Homo sapiens

Human Chemokine Panel

Human Immune Response

Human NFkB Pathway

Human Diabetes

Inventoried

Human_Immune

Human_Nfkb

Human_Diabetes

Human_Chemokine

Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene IL12B

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Function(s) Process(es)

MicroArray Probes:

Affymetrix

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR05027814.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR05027814.hg.1	NM_002187.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR05027814.hg.1	TC05001997.hg.1	HTA TC
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	TC0500012646.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	PSR0500188217.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	PSR0500188217.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	PSR0500188217.hg.1	ENST00000231228.2	Ensembl
Affymetrix Human Clariom D Assay	PSR0500188217.hg.1	NM_002187.2	Refseq
Affymetrix Human Clariom D Assay	PSR0500188217.hg.1	TC0500012646.hg.1	Clariom D TC

Citations (17)

Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification.

Authors: Carrithers MD, Dib-Hajj S, Carrithers LM, Tokmoulina G, Pypaert M, Jonas EA, Waxman SG
Journal: J Immunol - Page No 7822 (Fri Jun 15 00:00:00 UTC 2007)
Volume (Year): 178 (2007)
Product Usage: -

Adjuvant activity on murine and human macrophages.

Authors: Quesniaux V, Erard F, Ryffel B
Journal: Methods Mol Biol - Page No 117 (Fri Jan 01 00:00:00 UTC 2010)
Volume (Year): 626 (2010)
Product Usage: -

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

Authors: Makela SM, Strengell M, Pietila TE, Osterlund P, Julkunen I
Journal: J Leukoc Biol - Page No 664 (Wed Apr 01 00:00:00 UTC 2009)
Volume (Year): 85 (2009)
Product Usage: -

Inflammatory and microRNA Gene Expression as Prognostic Classifiers of Barrett's Associated Esophageal Adenocarcinoma.

Authors: Nguyen GH, Schetter AJ, Chou DB, Bowman ED, Zhao R, Hawkes JE, Mathe E, Kumamoto K, Zhao Y, Budhu A, Hagiwara N, Wang XW, Miyashita M, Casson AG, Harris CC
Journal: Clin Cancer Res - Page No (Mon Oct 25 00:00:00 UTC 2010)
Volume (Year): (2010)
Product Usage: -

Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: involvement of p38 and JNK kinase pathways.

Authors: Dobreva ZG, Stanilova SA, Miteva LD
Journal: Cytokine - Page No 76 (Tue Jul 01 00:00:00 UTC 2008)
Volume (Year): 43 (2008)
Product Usage: -

Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide.

Authors: Dower K, Ellis DK, Saraf K, Jelinsky SA, Lin LL
Journal: J Immunol - Page No 3520 (Sat Mar 01 00:00:00 UTC 2008)
Volume (Year): 180 (2008)
Product Usage: -

Expression of cytokine-associated genes in dendritic cells (DCs): comparison between adult peripheral blood- and umbilical cord blood-derived DCs by cDNA microarray.

Authors: Koga Y, Matsuzaki A, Suminoe A, Hattori H, Hara T
Journal: Immunol Lett - Page No 55 (Fri Feb 15 00:00:00 UTC 2008)
Volume (Year): 116 (2008)
Product Usage: -

Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.

Authors: Keller CC, Yamo O, Ouma C, Ong'echa JM, Ounah D, Hittner JB, Vulule JM, Perkins DJ
Journal: Infect Immun - Page No 5249 (Fri Sep 01 00:00:00 UTC 2006)
Volume (Year): 74 (2006)
Product Usage: -

Postmenopausal expression changes of immune system-related genes in human bone tissue.

Authors: Kosa JP, Balla B, Kiss J, Podani J, Takacs I, Lazary A, Nagy Z, Bacsi K, Karsai A, Speer G, Lakatos P
Journal: J Clin Immunol - Page No 761 (Sun Nov 01 00:00:00 UTC 2009)
Volume (Year): 29 (2009)
Product Usage: -

Characterization of the innate immune signalling pathways in hepatocyte cell lines.

Authors: Preiss S, Thompson A, Chen X, Rodgers S, Markovska V, Desmond P, Visvanathan K, Li K, Locarnini S, Revill P
Journal: J Viral Hepat - Page No 888 (Mon Dec 01 00:00:00 UTC 2008)
Volume (Year): 15 (2008)
Product Usage: -

Interactions among type I and type II interferon, tumor necrosis factor, and beta-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus.

Authors: Lee HM, Mima T, Sugino H, Aoki C, Adachi Y, Yoshio-Hoshino N, Matsubara K, Nishimoto N
Journal: Arthritis Res Ther - Page No R1 (Thu Jan 01 00:00:00 UTC 2009)
Volume (Year): 11 (2009)
Product Usage: -

Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes.

Authors: Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G
Journal: Infect Immun - Page No 845 (Mon Feb 01 00:00:00 UTC 2010)
Volume (Year): 78 (2010)
Product Usage: -

Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists.

Authors: Kamgang RK, Ramos I, Rodrigues Duarte L, Ghielmetti M, Freudenberg M, Dahinden C, Padovan E
Journal: Med Microbiol Immunol - Page No 369 (Mon Dec 01 00:00:00 UTC 2008)
Volume (Year): 197 (2008)
Product Usage: -

JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells.

Authors: Utsugi M, Dobashi K, Ono A, Ishizuka T, Hisada T, Koga Y, Shimizu Y, Kawata T, Matsuzaki S, Aoki H, Kamide Y, Mori M
Journal: Cytokine - Page No 127 (Sun Aug 01 00:00:00 UTC 2010)
Volume (Year): 51 (2010)
Product Usage: -

High expression of Foxp3, IL-23p19 and survivin mRNA in colorectal carcinoma.

Authors: Stanilov N, Miteva L, Mintchev N, Stanilova S
Journal: Int J Colorectal Dis - Page No 151 (Sun Feb 01 00:00:00 UTC 2009)
Volume (Year): 24 (2009)
Product Usage: -

An analysis of select pathogenic messages in lesional and non-lesional psoriatic skin using non-invasive tape harvesting.

Authors: Benson NR, Papenfuss J, Wong R, Motaal A, Tran V, Panko J, Krueger GG
Journal: J Invest Dermatol - Page No 2234 (Sun Oct 01 00:00:00 UTC 2006)
Volume (Year): 126 (2006)
Product Usage: -

Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide.

Authors: Barksby HE, Nile CJ, Jaedicke KM, Taylor JJ, Preshaw PM
Journal: Clin Exp Immunol - Page No 479 (Mon Jun 01 00:00:00 UTC 2009)
Volume (Year): 156 (2009)
Product Usage: -

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System Message

Genomic Map