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Gene Symbol:
BAX
Gene Name:
BCL2 associated X, apoptosis regulator
Gene Aliases:
BCL2L4
Chromosome Location:
Chr.19: 48954825 - 48961798 on Build GRCh38
Species:
Human
Species Specific ID (Flybase ID):
-
Assay ID Hs00180269_m1
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Catalog # 4331182
Price 244.00
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  • Genomic Map
  • Assay Details
  • More Information
  • Citations (15)

Genomic Map

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Assay Details

Gene Symbol: BAX
Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
RefSeq NM_001291428.1 NP_001278357.1 4 - 5 439 62
NM_001291429.1 NP_001278358.1 3 - 4 387 62
NM_001291430.1 NP_001278359.1 2 - 3 240 62
NM_001291431.1 NP_001278360.1 2 - 3 240 62
NM_004324.3 NP_004315.1 4 - 5 439 62
NM_138761.3 NP_620116.1 4 - 5 439 62
NM_138763.3 NP_620118.1 3 - 4 292 62
NM_138764.4 NP_620119.2 4 - 5 439 62
XM_017027077.1 XP_016882566.1 4 - 5 448 62
GenBank mRNA AF247393.1 - 4 - 5 370 62
AF250190.1 - 2 - 3 171 62
AJ417988.1 - 3 - 4 349 62
AJ586909.1 - 2 - 3 158 62
AJ586910.1 - 3 - 4 305 62
AK291076.1 - 4 - 5 419 62
BC014175.2 - 4 - 5 422 4578562 62
BM706954.1 - 2 - 3 252 62
CN281003.1 - 4 - 5 392 62
HQ889830.1 - 2 - 3 171 62
JX524562.1 - 3 - 4 319 62
KF830846.1 - 3 - 4 319 62
KF830847.1 - 3 - 4 319 62
KF830848.1 - 3 - 4 319 62
L22473.1 - 4 - 5 370 62
L22474.1 - 4 - 5 370 62
U19599.1 - 3 - 4 223 62

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More Information


Set Membership:

Amplicon length less than or equal to 70 Apoptosis Immune Tolerance Network Mammalian Gene Collection Recommended Assay Homo sapiens Human Pathogenesis of ALS Human Immune Response Human c-Myc and Apoptosis Human NGF Pathway Human Apoptotic Pathways triggered by HIV1 Human p53 Signaling Human Developmental Phases of Colorectal Cancer HUMAN COLORECTAL CANCER METASTASIS HUMAN MOLECULAR MECHANISMS OF CANCER HUMAN APOPTOSIS THROUGH DEATH RECEPTORS HUMAN P53 MEDIATED APOPTOSIS HUMAN IL-6 PATHWAY HUMAN CELLULAR APOPTOSIS PATHWAY Inventoried Human_c-Myc_and_Apoptosis Human_Immune Human_Developmental_Phases_of_Colorectal_Cancer Human_Pathogenesis_of_ALS Human_NGF_Pathway Human_p53_Signaling Human_Apoptotic_Pathways_Triggered_by_HIV1 Human_IL-6_Pathway Human_Apoptosis_through_Death_Receptors Human_Molecular_Mechanisms_of_Cancer Human_p53_Mediated_Apoptosis Human_Cellular_Apoptosis_Pathway Human_Colorectal_Cancer_Metastasis Probe spans exons

Gene Ontology Categories:

Function(s) Process(es)

ovarian follicle development
neuron migration
T cell homeostatic proliferation
B cell homeostasis
B cell apoptotic process
kidney development
release of cytochrome c from mitochondria
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
blood vessel remodeling
myeloid cell homeostasis
B cell negative selection
B cell homeostatic proliferation
positive regulation of B cell apoptotic process
glycosphingolipid metabolic process
regulation of nitrogen utilization
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
activation of signaling protein activity involved in unfolded protein response
inner mitochondrial membrane organization
outer mitochondrial membrane organization
germ cell development
aging
mitochondrial fusion
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
apoptotic mitochondrial changes
fertilization
response to toxic substance
response to salt stress
establishment or maintenance of transmembrane electrochemical gradient
response to gamma radiation
viral process
hypothalamus development
cerebral cortex development
negative regulation of protein binding
positive regulation of protein oligomerization
endoplasmic reticulum calcium ion homeostasis
negative regulation of endoplasmic reticulum calcium ion concentration
release of matrix enzymes from mitochondria
negative regulation of peptidyl-serine phosphorylation
regulation of mammary gland epithelial cell proliferation
glial cell apoptotic process
cellular response to UV
ectopic germ cell programmed cell death
response to cocaine
odontogenesis of dentin-containing tooth
response to drug
regulation of apoptotic process
positive regulation of apoptotic process
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
development of secondary sexual characteristics
cellular respiration
retinal cell programmed cell death
response to copper ion
positive regulation of developmental pigmentation
negative regulation of fibroblast proliferation
spermatid differentiation
post-embryonic camera-type eye morphogenesis
response to axon injury
homeostasis of number of cells within a tissue
protein oligomerization
protein homooligomerization
positive regulation of release of sequestered calcium ion into cytosol
neuron apoptotic process
response to corticosterone
regulation of mitochondrial membrane potential
Sertoli cell proliferation
retina development in camera-type eye
positive regulation of apoptotic process involved in mammary gland involution
vagina development
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
thymocyte apoptotic process
mitochondrion morphogenesis
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of release of cytochrome c from mitochondria
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
intrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
apoptotic process involved in patterning of blood vessels
apoptotic process involved in embryonic digit morphogenesis
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
positive regulation of apoptotic DNA fragmentation
positive regulation of IRE1-mediated unfolded protein response
B cell receptor apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of intrinsic apoptotic signaling pathway
protein binding
lipid binding
channel activity
heat shock protein binding
protein complex binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
chaperone binding
BH3 domain binding

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Citations (15)

The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
Authors
Scholz H, Lund T, Dahle MK, Collins JL, Korsgren O, Wang JE, Foss A
Journal
Diabetologia - Page No 1352 (Wed Jul 01 00:00:00 UTC 2009)
Volume (Year)
52 (2009)
Product Usage
-
MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival.
Authors
Forte E, Luftig MA
Journal
J Virol - Page No 2491 (Sun Mar 01 00:00:00 UTC 2009)
Volume (Year)
83 (2009)
Product Usage
-
Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2.
Authors
Ferrante E, Pellegrini C, Bondioni S, Peverelli E, Locatelli M, Gelmini P, Luciani P, Peri A, Mantovani G, Bosari S, Beck-Peccoz P, Spada A, Lania A
Journal
Endocr Relat Cancer - Page No 955 (Fri Sep 01 00:00:00 UTC 2006)
Volume (Year)
13 (2006)
Product Usage
-
Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells.
Authors
Soto-Cerrato V, Montaner B, Martinell M, Vilaseca M, Giralt E, Perez-Tomas R
Journal
Biochem Pharmacol - Page No 32 (Mon Dec 19 00:00:00 UTC 2005)
Volume (Year)
71 (2005)
Product Usage
-
Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction.
Authors
Stein A, Knodler M, Makowski M, Kuhnel S, Nekolla S, Keithahn A, Weidl E, Groha P, Schurmann M, Saraste A, Botnar R, Oostendorp RA, Ott I
Journal
Bmc Cardiovasc Disord - Page No 43 (Fri Jan 01 00:00:00 UTC 2010)
Volume (Year)
10 (2010)
Product Usage
-
Quantitative evaluation of the apoptosis regulating genes Survivin, Bcl-2 and Bax in inflammatory and malignant pleural lesions.
Authors
Falleni M, Pellegrini C, Marchetti A, Roncalli M, Nosotti M, Palleschi A, Santambrogio L, Coggi G, Bosari S
Journal
Lung Cancer - Page No 211 (Sun May 01 00:00:00 UTC 2005)
Volume (Year)
48 (2005)
Product Usage
-
The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin.
Authors
Song J, Jie C, Polk P, Shridhar R, Clair T, Zhang J, Yin L, Keppler D
Journal
Biochem Biophys Res Commun - Page No 175 (Fri Feb 03 00:00:00 UTC 2006)
Volume (Year)
340 (2006)
Product Usage
-
High radiosensitivity of germ cells in human male fetus.
Authors
Lambrot R, Coffigny H, Pairault C, Lecureuil C, Frydman R, Habert R, Rouiller-Fabre V
Journal
J Clin Endocrinol Metab - Page No 2632 (Sun Jul 01 00:00:00 UTC 2007)
Volume (Year)
92 (2007)
Product Usage
-
DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (TP53, p21CDKN1A, BCL2 and BAX) with respect to occupational exposure to styrene.
Authors
Hanova M, Vodickova L, Vaclavikova R, Smerhovsky Z, Stetina R, Hlavac P, Naccarati A, Slyskova J, Polakova V, Soucek P, Kumar R, Hemminki K, Vodicka P
Journal
Carcinogenesis - Page No (Thu Oct 21 00:00:00 UTC 2010)
Volume (Year)
 (2010)
Product Usage
-
Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes.
Authors
Grcevic D, Kusec R, Kovacic N, Lukic A, Lukic IK, Ivcevic S, Nemet D, Seiwerth RS, Ostojic SK, Croucher PI, Marusic A
Journal
Leuk Res - Page No 742 (Tue Jun 01 00:00:00 UTC 2010)
Volume (Year)
34 (2010)
Product Usage
-
c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs.
Authors
Abaza MS, Al-Saffar A, Al-Sawan S, Al-Attiyah R
Journal
Tumour Biol - Page No 287 (Tue Jan 01 00:00:00 UTC 2008)
Volume (Year)
29 (2008)
Product Usage
-
IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.
Authors
Ning Y, Riggins RB, Mulla JE, Chung H, Zwart A, Clarke R
Journal
Mol Cancer Ther - Page No 1274 (Sat May 01 00:00:00 UTC 2010)
Volume (Year)
9 (2010)
Product Usage
-
Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation.
Authors
Cho SW, Hartle L, Son SM, Yang F, Goldberg M, Xu Q, Langer R, Anderson DG
Journal
Biochem Biophys Res Commun - Page No 158 (Fri Nov 07 00:00:00 UTC 2008)
Volume (Year)
376 (2008)
Product Usage
-
Modeled gravitational unloading triggers differentiation and apoptosis in preosteoclastic cells.
Authors
Monici M, Fusi F, Paglierani M, Marziliano N, Cogoli A, Pratesi R, Bernabei PA
Journal
J Cell Biochem - Page No 65 (Mon May 01 00:00:00 UTC 2006)
Volume (Year)
98 (2006)
Product Usage
-
Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.
Authors
Ni Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ
Journal
J Biol Chem - Page No (Tue Nov 02 00:00:00 UTC 2010)
Volume (Year)
 (2010)
Product Usage
-

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