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Invitrogen
p130 Polyclonal Antibody
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Product Details
PA5-82690
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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Product Specific Information
Immunogen sequence: IAGSPLTPRR VTEVRADTGG LGRSITSPTT LYDRYSSPPA STTRRRLFVE NDSPSDGGTP GRMPPQPLVN AVPVQNVSGE TVSVTPVPGQ TLVTMATATV TANNGQTVTI PVQGIANENG GITFFPVQV
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PRB2; rb2 p130; RBR-2; retinoblastoma-like 2; Retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Aliases: P130; RB2; RBL2
UniProt ID: (Human) Q08999
Entrez Gene ID: (Human) 5934
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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