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Invitrogen
mGluR7 Polyclonal Antibody
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Product Details
PA5-33829
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
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RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Elephant, Bovine (100%).
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FLJ40498; glutamate receptor; glutamate receptor, metabotropic 7; Metabotropic glutamate receptor 7; mGluR7; protein phosphatase 1, regulatory subunit 87
Gene Aliases: BOS_20725; GLUR7; GPRC1G; GRM7; MGLU7; MGLUR7; PPP1R87
UniProt ID: (Human) Q14831
Entrez Gene ID: (Human) 2917, (Bovine) 535362
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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