Invitrogen

cIAP2 Polyclonal Antibody

Name: cIAP2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-19514

View all (34) cIAP2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)

cIAP2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 3

cIAP2 Antibody (PA5-19514) in ICC/IF

Immunofluorescent staining of HeLa cells using Product # PA5-19514, anti-cIAP2 antibody. The cells were fixed with methanol (100%) for 5 minutes and exposed to the primary antibody at a concentration of 1 µg/mL for 1 hour at room temp. The secondary antibody was a 448 fluorescence conjugated Goat anti-rabbit IgG (green) at a dilution of 1:1000. A WGA- 594 fluorescent conjugated stain was used to label plasma membranes (red) and the nuclei stain was DAPI (blue).

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Immunogen Image cIAP2 Polyclonal Antibody

Product Details

PA5-19514

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

Immunocytochemistry (ICC/IF)

1 µg/mL

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Human cIAP2.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_10986934

Product Specific Information

For Western Blot, this antibody has non-specific bands at 150 kDa,35 kDa and 75 kDa.

This antibody is predicted to react with mouse, rat, chicken and dog based on sequence homology.

Target Information

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIP 2; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1

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Gene Aliases: AIP1; API2; Birc2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; IAP1; MALT2; MIHC; RNF49

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UniProt ID: (Human) Q13489

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Entrez Gene ID: (Human) 330, (Rat) 78971

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Function(s)

ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Process(es)

apoptotic process cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling spermatogenesis regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein ubiquitination positive regulation of protein ubiquitination tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of innate immune response regulation of inflammatory response protein heterooligomerization regulation of necroptotic process negative regulation of necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity negative regulation of phosphorylation necroptotic process negative regulation of reactive oxygen species metabolic process

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cIAP2 Polyclonal Antibody

cIAP2 Antibody (PA5-19514) in ICC/IF

Product Details

PA5-19514

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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