Fabgennix

cIAP2 Polyclonal Antibody

View all (34) cIAP2 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

CIAP2-201AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 545-620 on human cIAP2 protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Target Information

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIP 2; API2; apoptosis inhibitor 1; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; mIAP-1; mIAP1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1

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Gene Aliases: AIP1; Api1; API2; AW107670; Birc2; BIRC3; c-IAP2; cIAP-1; cIAP-2; cIAP1; CIAP2; HAIP1; HIAP1; HIAP2; IAP1; IAP2; MALT2; MIAP1; MIAP2; MIHB; MIHC; RNF49

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UniProt ID: (Human) Q13489, (Mouse) O08863

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Entrez Gene ID: (Human) 330, (Mouse) 11796, (Rat) 78971

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Function(s)
ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
apoptotic process cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling spermatogenesis regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein ubiquitination positive regulation of protein ubiquitination tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of innate immune response regulation of inflammatory response protein heterooligomerization regulation of necroptotic process negative regulation of necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity negative regulation of phosphorylation necroptotic process negative regulation of reactive oxygen species metabolic process
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