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Invitrogen
cGAS Polyclonal Antibody
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Product Details
PA5-43855
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
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Product Specific Information
Peptide sequence: VPKHAKEGNG FQEETWRLSF SHIEKEILNN HGKSKTCCEN KEEKCCRKDC
Sequence homology: Cow: 86%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Pig: 93%; Rabbit: 100%
Target Information
cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 2'3'-cGAMP synthase; C6orf150; cGAMP synthase; Cyclic GMP-AMP synthase; h-cGAS; Mab-21 domain-containing protein 1; MB21D1; protein MB21D1
Gene Aliases: C6orf150; CGAS; h-cGAS; MB21D1
UniProt ID: (Human) Q8N884
Entrez Gene ID: (Human) 115004
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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