Invitrogen

c-Cbl Monoclonal Antibody (M159)

View all (49) c-Cbl antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-47701

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

M159

Immunogen

Clone (M159) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human c-Cbl. This sequence is highly conserved in rat and mouse c-Cbl.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.0625 mg/mL

Purification

Protein A

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942682

Product Specific Information

The antibody detects a 120 kDa* protein in human Jurkat cells.

Target Information

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL

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Gene Aliases: 4732447J05Rik; C-CBL; CBL; Cbl-2; CBL2; FRA11B; NSLL; RGD1561386; RNF55

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UniProt ID: (Human) P22681, (Mouse) P22682

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Entrez Gene ID: (Human) 867, (Mouse) 12402, (Rat) 500985

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Function(s)
phosphotyrosine binding transcription factor activity, sequence-specific DNA binding ubiquitin-protein transferase activity signal transducer activity calcium ion binding protein binding zinc ion binding ligase activity SH3 domain binding protein kinase binding ephrin receptor binding ubiquitin protein ligase activity cadherin binding involved in cell-cell adhesion UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
regulation of transcription, DNA-templated cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway fibroblast growth factor receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling protein ubiquitination negative regulation of epidermal growth factor receptor signaling pathway protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of receptor-mediated endocytosis cell-cell adhesion regulation of signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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