Invitrogen

beta Catenin Monoclonal Antibody (CAT-5H10)

Advanced Verification
71 Published Figures
175 References
View all (238) beta Catenin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

13-8400

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
View 47 publications 47 publications

Immunohistochemistry (IHC)

-
View 28 publications 28 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100
View 28 publications 28 publications

Immunohistochemistry (Frozen) (IHC (F))

-
View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

Assay-dependent
View 35 publications 35 publications

Flow Cytometry (Flow)

-
View 1 publication 1 publication

ELISA (ELISA)

-
View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent
View 5 publications 5 publications

in situ PLA (PLA)

-
View 2 publications 2 publications

Miscellaneous PubMed (MISC)

-
View 25 publications 25 publications
Product Specifications

Species Reactivity

Chicken, Human, Mouse

Published species

Bovine, C. elegans, Chicken, Dog, Human, Mouse, Rat, Rhesus monkey

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

CAT-5H10

Immunogen

Fusion protein consisting of the maltose binding protein fused to a 100 amino acid segment of the C-terminus of chicken beta-Catenin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533039

Target Information

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Bcatenin; beta 1 88kDa; beta catenin; Beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; Catenin beta-1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; β catenin; βcatenin

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Gene Aliases: armadillo; Bfc; Catnb; CHBCAT; CTNNB; CTNNB1; Mesc; MRD19; OK/SW-cl.35; PRO2286

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UniProt ID: (Human) P35222, (Mouse) Q02248

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Entrez Gene ID: (Chicken) 395964, (Human) 1499, (Mouse) 12387

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Function(s)
RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity signal transducer activity protein binding protein C-terminus binding transcription factor binding enzyme binding kinase binding protein kinase binding protein phosphatase binding estrogen receptor binding protein complex binding ionotropic glutamate receptor binding nuclear hormone receptor binding transcription regulatory region DNA binding ion channel binding alpha-catenin binding cadherin binding SMAD binding androgen receptor binding nitric-oxide synthase binding I-SMAD binding repressing transcription factor binding cadherin binding involved in cell-cell adhesion euchromatin binding DNA binding chromatin binding R-SMAD binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter embryonic axis specification cell morphogenesis involved in differentiation skeletal system development patterning of blood vessels vasculogenesis branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second endoderm formation cell fate specification cell fate determination endodermal cell fate commitment neuron migration kidney development neural plate development vasculature development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation lens morphogenesis in camera-type eye ventricular compact myocardium morphogenesis regulation of secondary heart field cardioblast proliferation mesenchymal to epithelial transition involved in metanephros morphogenesis metanephros morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell adhesion cell-matrix adhesion chemical synaptic transmission ectoderm development nervous system development glial cell fate determination heart development cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation anterior/posterior axis specification dorsal/ventral axis specification dorsal/ventral pattern formation proximal/distal pattern formation cellular process regulation of gene expression positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Schwann cell proliferation Wnt signaling pathway morphogenesis of embryonic epithelium single organismal cell-cell adhesion stem cell population maintenance layer formation in cerebral cortex central nervous system vasculogenesis hair cycle process hemopoiesis cell differentiation T cell differentiation osteoclast differentiation lung development male genitalia development regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation forebrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol T cell differentiation in thymus negative regulation of protein sumoylation response to cytokine adherens junction organization adherens junction assembly protein localization to cell surface cellular protein localization embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic skeletal limb joint morphogenesis regulation of cell proliferation regulation of T cell proliferation odontogenesis of dentin-containing tooth regulation of cell fate specification embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade skin development response to estrogen canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition canonical Wnt signaling pathway involved in negative regulation of apoptotic process bone resorption regulation of cell differentiation negative regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic chromatin-mediated maintenance of transcription cell maturation synaptic vesicle transport animal organ development thymus development oocyte development embryonic foregut morphogenesis regulation of smooth muscle cell proliferation negative regulation of oligodendrocyte differentiation synapse organization smooth muscle cell differentiation protein heterooligomerization positive regulation of telomerase activity cardiac muscle cell proliferation oviduct development canonical Wnt signaling pathway limb development trachea morphogenesis trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development mesenchyme development lung induction epithelial cell differentiation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation mesenchymal cell proliferation involved in lung development cardiac vascular smooth muscle cell differentiation coronary artery morphogenesis epicardium-derived cardiac vascular smooth muscle cell differentiation positive regulation of branching involved in lung morphogenesis endothelial tube morphogenesis fungiform papilla formation canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation sympathetic ganglion development regulation of centromeric sister chromatid cohesion cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to indole-3-methanol renal system development renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation mesenchyme morphogenesis regulation of nephron tubule epithelial cell differentiation regulation of calcium ion import negative regulation of neuron death cellular response to insulin-like growth factor stimulus regulation of protein localization to cell surface positive regulation of determination of dorsal identity negative regulation of apoptotic signaling pathway epithelial to mesenchymal transition liver development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Wnt signaling pathway, calcium modulating pathway midgut development response to activity androgen receptor signaling pathway hindbrain development positive regulation of type I interferon production hair cell differentiation catenin import into nucleus response to drug proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus myoblast differentiation regulation of angiogenesis response to cadmium ion regulation of fibroblast proliferation positive regulation of skeletal muscle tissue development embryonic cranial skeleton morphogenesis regulation of neurogenesis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of muscle cell differentiation positive regulation of histone H3-K4 methylation cranial ganglion development cellular response to lithium ion positive regulation of chromatin-mediated maintenance of transcription regulation of euchromatin binding regulation of core promoter binding beta-catenin-TCF complex assembly beta-catenin destruction complex disassembly midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation embryonic brain development dorsal root ganglion development positive regulation of DNA-templated transcription, initiation
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