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Invitrogen
alpha Internexin Polyclonal Antibody
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FIGURE: 1 / 2
alpha Internexin Antibody (PA1-10017) in ICC/IF
Product Details
PA1-10017
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Storage buffer
Contains
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RRID
Product Specific Information
In Western blot, a prominent band at ~66 kDa is observed, as well as smaller lower bands which are apparently degradation products. A minor band at ~150 kDa is also seen, resulting from dimerization of alpha-internexin.
Target Information
alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 66 kDa neurofilament protein; Alpha-internexin; Alpha-Inx; FLJ18662; FLJ57501; internexin neuronal intermediate filament protein, alpha; internexin, alpha; MGC12702; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; NF-66
Gene Aliases: AV028420; INA; Inexa; Intlaa; NEF5; NF-66; NF66; TXBP-1
UniProt ID: (Human) Q16352, (Bovine) Q08DH7, (Mouse) P46660
Entrez Gene ID: (Human) 9118, (Bovine) 532236, (Mouse) 226180, (Rat) 24503
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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