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Proteintech
ZRANB3 Polyclonal Antibody
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Product Details
23111-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: LPVYDTLMF CASRNTDRIH IYTKDGKQMS CNFIPLDIKL DLWEDLPASF QLKQYRSLIL RFVREWSSLT AMKQRIIRKS GQLFCSPILA LEEITKQQTK QNCTKRYITK EDVAVASMDK VKNVGGHVRL ITKESRPRDP FTKKLLEDGA CVPFLNPYTV QADLTVKPST SKGYLQAVDN EGNPLCLRCQ QPTCQTKQAC KANSWDSRFC SLKCQEEFWI RSNNSYLRAK VFETEHGVCQ LCNVNAQELF LRLRDAPKSQ RKNLLYATWT SKLPLEQLNE MIRNPGEGHF WQVDHIKPVY GGGGQCSLDN LQTLCTVCHK ERTARQAKER SQVRRQSLAS KHGSDITRFL VKK (728-1079 aa encoded by B C064616)
Target Information
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AH2; Annealing helicase 2; DNA annealing helicase and endonuclease ZRANB3; Zinc finger Ran-binding domain-containing protein 3; zinc finger, RAN-binding domain containing 3
Gene Aliases: 4933425L19Rik; AH2; ZRANB3
UniProt ID: (Human) Q5FWF4
Entrez Gene ID: (Human) 84083
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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