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Invitrogen
ZO-3 Polyclonal Antibody
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FIGURE: 1 / 23
ZO-3 Antibody (36-4100) in ICC/IF
Product Details
36-4100
Species Reactivity
Published species
Host/Isotype
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Immunogen
Conjugate
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Purification
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Target Information
ZO-3 is a member of the membrane associated guanylate kinse (MAGUK) family and are considered tight junction-associated proteins. Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. ZO-3 is believed to have both structural and signaling roles, and is characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Tight junction protein 3; tight junction protein 3 (zona occludens 3); Tight junction protein ZO-3; TJP-3; Zona occludens protein 3; Zonula occludens protein 3
Gene Aliases: TJP3; ZO-3; ZO3
UniProt ID: (Human) O95049
Entrez Gene ID: (Human) 27134, (Dog) 403852, (Mouse) 27375, (Rat) 314640
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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