Invitrogen

WNT4 Polyclonal Antibody

View all (20) WNT4 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-34323

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Dog, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 14 amino acid peptide from internal region of human WNT4.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551675

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse, Pig (100%) Opossum (86%).

Target Information

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Protein Wnt-4; signal molecule; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4

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Gene Aliases: I79_010503; SERKAL; UNQ426/PRO864; WNT-4; WNT4

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UniProt ID: (Human) P56705, (Rat) Q9QXQ5, (Mouse) P22724

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Entrez Gene ID: (Pig) 100327037, (Dog) 612367, (Human) 54361, (Rat) 84426, (Chinese hamster) 100769003, (Mouse) 22417

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Function(s)
transcription corepressor activity frizzled binding receptor agonist activity molecular_function receptor binding protein binding
Process(es)
metanephros development branching involved in ureteric bud morphogenesis kidney development mesonephros development epithelial to mesenchymal transition embryonic epithelial tube formation liver development androgen biosynthetic process gamete generation sex differentiation male gonad development female gonad development cellular response to starvation negative regulation of gene expression negative regulation of steroid biosynthetic process Wnt signaling pathway protein palmitoylation regulation of cell-cell adhesion cell differentiation neuron differentiation female sex determination adrenal gland development negative regulation of cell migration positive regulation of bone mineralization positive regulation of aldosterone biosynthetic process response to estradiol positive regulation of collagen biosynthetic process T cell differentiation in thymus immature T cell proliferation in thymus tube morphogenesis non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway via MAPK cascade negative regulation of fibroblast growth factor receptor signaling pathway hormone metabolic process cell fate commitment negative regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of meiotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated oocyte development branching morphogenesis of an epithelial tube anatomical structure development smooth muscle cell differentiation positive regulation of stress fiber assembly positive regulation of focal adhesion assembly canonical Wnt signaling pathway somatotropin secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation mesenchymal to epithelial transition tertiary branching involved in mammary gland duct morphogenesis kidney morphogenesis negative regulation of wound healing mammary gland epithelium development positive regulation of dermatome development paramesonephric duct development negative regulation of testicular blood vessel morphogenesis cellular response to estradiol stimulus cellular response to hydrostatic pressure cellular response to transforming growth factor beta stimulus nephron development renal vesicle formation renal vesicle induction mesonephric tubule development metanephric tubule formation metanephric nephron development metanephric nephron morphogenesis establishment of protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway negative regulation of male gonad development positive regulation of cortisol biosynthetic process negative regulation of testosterone biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of GTPase activity metanephric mesenchymal cell differentiation signal transduction cell-cell signaling multicellular organism development
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