Invitrogen

WNT4 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
WNT4 Polyclonal Antibody

Product Details

PA1-9118

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunocytochemistry (ICC/IF)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Internal sequence corresponding to amino acids C-SNWLYLAKLSSVGS (aa 23-37).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2257215

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

Target Information

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Protein Wnt-4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4

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Gene Aliases: SERKAL; UNQ426/PRO864; WNT-4; WNT4

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UniProt ID: (Human) P56705

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Entrez Gene ID: (Human) 54361

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Function(s)
transcription corepressor activity frizzled binding receptor agonist activity
Process(es)
branching involved in ureteric bud morphogenesis kidney development epithelial to mesenchymal transition embryonic epithelial tube formation liver development androgen biosynthetic process male gonad development female gonad development cellular response to starvation negative regulation of gene expression negative regulation of steroid biosynthetic process Wnt signaling pathway regulation of cell-cell adhesion neuron differentiation female sex determination adrenal gland development negative regulation of cell migration positive regulation of bone mineralization positive regulation of aldosterone biosynthetic process positive regulation of collagen biosynthetic process immature T cell proliferation in thymus non-canonical Wnt signaling pathway via MAPK cascade negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of GTPase activity cell fate commitment negative regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of meiotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated oocyte development smooth muscle cell differentiation positive regulation of stress fiber assembly positive regulation of focal adhesion assembly canonical Wnt signaling pathway somatotropin secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation mesenchymal to epithelial transition tertiary branching involved in mammary gland duct morphogenesis negative regulation of wound healing mammary gland epithelium development positive regulation of dermatome development paramesonephric duct development negative regulation of testicular blood vessel morphogenesis cellular response to transforming growth factor beta stimulus renal vesicle formation renal vesicle induction metanephric mesenchymal cell differentiation metanephric tubule formation metanephric nephron morphogenesis establishment of protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway negative regulation of male gonad development positive regulation of cortisol biosynthetic process negative regulation of testosterone biosynthetic process negative regulation of apoptotic signaling pathway
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