Invitrogen

VDR Recombinant Rabbit Monoclonal Antibody (2R1F6)

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Datasheet
Protocols
Questions & Answers
VDR Recombinant Rabbit Monoclonal Antibody (2R1F6)

Product Details

MA5-51200

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2R1F6

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093909

Product Specific Information

Immunogen sequence: MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1,25-dihydroxyvitamin D3 receptor; HGNC:12679; Nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; VDR; vitamin D nuclear receptor variant 1; vitamin D receptor; Vitamin D3 receptor

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Gene Aliases: NR1I1; PPP1R163; VDR

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UniProt ID: (Human) P11473, (Mouse) P48281

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Entrez Gene ID: (Human) 7421, (Mouse) 22337

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding zinc ion binding calcitriol receptor activity lithocholic acid receptor activity sequence-specific DNA binding retinoid X receptor binding vitamin D response element binding calcitriol binding lithocholic acid binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding vitamin D binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis skeletal system development transcription initiation from RNA polymerase II promoter calcium ion transport cellular calcium ion homeostasis signal transduction lactation negative regulation of cell proliferation positive regulation of gene expression negative regulation of keratinocyte proliferation positive regulation of vitamin D 24-hydroxylase activity bile acid signaling pathway steroid hormone mediated signaling pathway positive regulation of keratinocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter decidualization intestinal absorption positive regulation of apoptotic process involved in mammary gland involution regulation of calcidiol 1-monooxygenase activity mammary gland branching involved in pregnancy vitamin D receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development organ morphogenesis intracellular receptor signaling pathway regulation of calcium ion transport apoptotic signaling pathway
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