Invitrogen

VDR Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
VDR Polyclonal Antibody

Product Details

PA5-95259

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human VDR (377-402aa HLLYAKMIQKLADLRSLNEEHSKQYR).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807063

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Human Placenta Tissue, Rat Kidney Tissue, Rat Liver Tissue, Rat Pancreas Tissue, HELA whole cell. IHC: mouse intestine tissue, rat intestine tissue, human intestinal cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1,25-dihydroxyvitamin D3 receptor; HGNC:12679; Nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; VDR; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; Vitamin D3 receptor

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Gene Aliases: NR1I1; PPP1R163; VDR

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UniProt ID: (Human) P11473, (Rat) P13053, (Mouse) P48281

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Entrez Gene ID: (Human) 7421, (Rat) 24873, (Mouse) 22337

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding zinc ion binding calcitriol receptor activity lithocholic acid receptor activity sequence-specific DNA binding retinoid X receptor binding vitamin D response element binding calcitriol binding lithocholic acid binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding vitamin D binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis skeletal system development transcription initiation from RNA polymerase II promoter calcium ion transport cellular calcium ion homeostasis signal transduction lactation negative regulation of cell proliferation positive regulation of gene expression negative regulation of keratinocyte proliferation positive regulation of vitamin D 24-hydroxylase activity bile acid signaling pathway steroid hormone mediated signaling pathway positive regulation of keratinocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter decidualization intestinal absorption positive regulation of apoptotic process involved in mammary gland involution regulation of calcidiol 1-monooxygenase activity mammary gland branching involved in pregnancy vitamin D receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development heart development aging organ morphogenesis intracellular receptor signaling pathway response to estradiol response to calcium ion regulation of calcium ion transport cellular response to vitamin D apoptotic signaling pathway
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