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Invitrogen
UNC5B Polyclonal Antibody
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FIGURE: 1 / 2
UNC5B Antibody (PA5-47038) in IHC (P)
Product Details
PA5-47038
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Shipping conditions
RRID
Product Specific Information
In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) UNC5H3 and recombinant rat UNC5H1 is observed, and less than 1% cross-reactivity with rhUNC5H4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: C. elegans; Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; transmembrane receptor Unc5H2; unc-5 homolog 2
Gene Aliases: Unc5b; Unc5h2
UniProt ID: (Rat) O08722
Entrez Gene ID: (Rat) 60630
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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