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  • Primary Antibodies ›
  • UNC13B Antibodies

Invitrogen

UNC13B Polyclonal Antibody

View all (6) UNC13B antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite UNC13B Polyclonal Antibody

  • Antibody Testing Data (4)
UNC13B Antibody in Immunocytochemistry (ICC/IF)
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UNC13B Antibody in Immunocytochemistry (ICC/IF)
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UNC13B Antibody (PA5-22153) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of UNC13B was performed in DIV9 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: UNC13B Polyclonal Antibody (Product # PA5-22153) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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UNC13B Antibody in Immunocytochemistry (ICC/IF)
UNC13B Antibody in Immunocytochemistry (ICC/IF)
UNC13B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
UNC13B Antibody in Western Blot (WB)

Product Details

PA5-22153

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human UNC13B. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11156788

Product Specific Information

Recommended positive controls: 293T, H1299, HeLa, HepG2.

Predicted reactivity: Mouse (99%), Rat (98%), Bovine (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B

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Gene Aliases: MUNC13; Munc13-2; UNC13; UNC13B; Unc13h2

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UniProt ID: (Human) O14795, (Rat) Q62769

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Entrez Gene ID: (Human) 10497, (Rat) 64830

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Function(s)
signal transducer activity receptor activity protein binding diacylglycerol binding metal ion binding
Process(es)
apoptotic process signal transduction chemical synaptic transmission neurotransmitter secretion neuromuscular junction development excretion positive regulation of synaptic vesicle priming glutamate secretion synaptic vesicle docking synaptic vesicle priming synaptic transmission, glutamatergic intracellular signal transduction regulation of short-term neuronal synaptic plasticity innervation positive regulation of inhibitory postsynaptic potential
It has to be done as per old AB suggested Products section.
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