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Invitrogen
TYROBP Polyclonal Antibody
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FIGURE: 1 / 5
TYROBP Antibody (PA5-26861) in IHC (P)
Product Details
PA5-26861
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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RRID
Product Specific Information
This antibody is predicted to react with bovine based on sequence homology.
Target Information
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DNAX-activation protein 12; KAR-associated protein; Killer-activating receptor-associated protein; TYRO protein tyrosine kinase-binding protein
Gene Aliases: DAP12; KARAP; PLOSL; TYROBP
UniProt ID: (Human) O43914
Entrez Gene ID: (Human) 7305
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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