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Proteintech
TSHR Polyclonal Antibody
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Product Details
14450-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Product Specific Information
This rabbit polyclonal antibody raised against N-terminal region (1-253 aa) of human TSHR can detect subunit A with an experimentally determined molecular weight of 62-70 kDa under reducing condition.
Immunogen sequence: MRPADLLQL VLLLDLPRDL GGMGCSSPPC ECHQEEDFRV TCKDIQRIPS LPPSTQTLKL IETHLRTIPS HAFSNLPNIS RIYVSIDVTL QQLESHSFYN LSKVTHIEIR NTRNLTYIDP DALKELPLLK FLGIFNTGLK MFPDLTKVYS TDIFFILEIT DNPYMTSIPV NAFQGLCNET LTLKLYNNGF TSVQGYAFNG TKLDAVYLNK NKYLTVIDKD AFGGVYSGPS LLLPLGRKSL SFETQKAPRS SMPS (1-253 aa encoded by BC063613)
Target Information
TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R
Gene Aliases: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; pet; TSHR; TSHRA
UniProt ID: (Human) P16473, (Mouse) P47750, (Rat) P21463
Entrez Gene ID: (Human) 7253, (Mouse) 22095, (Rat) 25360
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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